PDO and the PDO_SQLITE driver is enabled by default. You may need to enable the PDO driver for your database of choice; consult the documentation for database-specific PDO drivers to find out more about that.

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When building PDO as a shared extension (not recommended) then all PDO drivers must be loaded after PDO itself.

When installing PDO as a shared module, the php.ini file needs to be updated so that the PDO extension will be loaded automatically when PHP runs. You will also need to enable any database specific drivers there too; make sure that they are listed after the pdo.so line, as PDO must be initialized before the database-specific extensions can be loaded. If you built PDO and the database-specific extensions statically, you can skip this step.

extension=pdo.so

Choose the other database-specific DLL files and either use dl() to load them at runtime, or enable them in php.ini below php_pdo.dll. For example:

extension=php_pdo.dll
extension=php_pdo_firebird.dll
extension=php_pdo_informix.dll
extension=php_pdo_mssql.dll
extension=php_pdo_mysql.dll
extension=php_pdo_oci.dll
extension=php_pdo_oci8.dll
extension=php_pdo_odbc.dll
extension=php_pdo_pgsql.dll
extension=php_pdo_sqlite.dll  

These DLLs should exist in the system's extension_dir.